Outcomes of the Multimodal Treatment of Malignant Pleural Mesiothelioma: The Role of Surgery
10.5090/kjtcs.2018.51.1.35
- Author:
Bub Se NA
1
;
Ji Seong KIM
;
Kwanyong HYUN
;
In Kyu PARK
;
Chang Hyun KANG
;
Young Tae KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Korea. ikpark@snu.ac.kr
- Publication Type:Multicenter Study
- Keywords:
Mesothelioma;
Surgery;
Prognosis
- MeSH:
Chylothorax;
Combined Modality Therapy;
Hospital Mortality;
Humans;
Korea;
Mesothelioma;
Pneumonectomy;
Pneumonia;
Postoperative Complications;
Prognosis;
Prospective Studies;
Pulmonary Embolism;
Retrospective Studies;
Survival Rate;
Tachycardia;
Wounds and Injuries
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2018;51(1):35-40
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The treatment of malignant pleural mesothelioma (MPM) is challenging, and multimodal treatment including surgery is recommended; however, the role of surgery is debated. The treatment outcomes of MPM in Korea have not been reported. We analyzed the outcomes of MPM in the context of multimodal treatment, including surgery. METHODS: The records of 29 patients with pathologically proven MPM from April 1998 to July 2015 were retrospectively reviewed. The treatment outcomes of the surgery and non-surgery groups were compared. RESULTS: The overall median survival time was 10.6 months, and the overall 3-year survival rate was 25%. No postoperative 30-day or in-hospital mortality occurred in the surgery group. Postoperative complications included tachyarrhythmia (n=4), pulmonary thromboembolism (n=1), pneumonia (n=1), chylothorax (n=1), and wound complications (n=3). The treatment outcomes between the surgery and non-surgery groups were not significantly different (3-year survival rate: 31.3% vs. 16.7%, respectively; p=0.47). In a subgroup analysis, there was no significant difference in the treatment outcomes between the extrapleural pneumonectomy group and the non-surgery group (3-year survival rate: 45.5% vs. 16.7%, respectively; p=0.23). CONCLUSION: Multimodal treatment incorporating surgery did not show better outcomes than non-surgical treatment. A nationwide multicenter data registry and prospective randomized controlled studies are necessary to optimize the treatment of MPM.
