Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
- Author:
Gabriela MUÑOZ
1
;
Camilo VERGARA
;
Gabriela MARTÍNEZ
;
Werner APT
;
Inés ZULANTAY
Author Information
- Publication Type:Brief Communication
- Keywords: IFA; ELISA; chronic Chagas disease; IgG; nifurtimox; follow-up
- MeSH: Chagas Disease; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Immunoglobulin G; Immunoglobulins; Nifurtimox; Trypanosoma cruzi; Trypanosoma
- From:The Korean Journal of Parasitology 2019;57(1):39-41
- CountryRepublic of Korea
- Language:English
- Abstract: In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
