Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis
10.3347/kjp.2018.56.2.147
- Author:
Bahman RAHIMI-ESBOEI
1
;
Mohammad ZAREI
;
Mehdi MOHEBALI
;
Hossein Keshavarz VALIAN
;
Saeedeh SHOJAEE
;
Raziyeh MAHMOUDZADEH
;
Mirataollah SALABATI
Author Information
1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. hkeshavarz@tums.ac.ir
- Publication Type:Original Article
- Keywords:
Toxoplasma gondii;
IgG;
IgM;
IgG avidity;
ocular toxoplasmosis
- MeSH:
Antibodies;
Diagnosis;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Iran;
Prospective Studies;
Serologic Tests;
Toxoplasma;
Toxoplasmosis, Ocular
- From:The Korean Journal of Parasitology
2018;56(2):147-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti-Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti-T. gondii IgG, and 8 cases were positive for anti-T. gondii IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6.8% and 9.4% of cases were positive for IgM and IgG avidity tests, respectively (P=0.632). Agreement (Kappa value) between paired tests IgG-IgM, IgG-IgG avidity, and IgM-IgG avidity was 0.080, 0.099, and 0.721, respectively (P < 0.05). This study showed that conventional serologic tests (IgM and IgG levels) and IgG avidity correlate well each other and can be used to differentiate recent infections from old OT. It seems that reactivated old infections rather than recently acquired infections are majority of Iranian OT patients.
