A clinical study of calciportriol ointment(MC 903) in the treatment of psoriasis.
- Author:
Tae Jin YOON
;
Jin Hwan KIM
;
Woo Young SIM
;
Mu Hyoung LEE
;
Nack In KIM
;
Choong Rim HAW
- Publication Type:In Vitro ; Original Article
- Keywords:
Calcipotriol(MC 903);
Psoriasis
- MeSH:
Calcium;
Cholecalciferol;
Humans;
Keratinocytes;
Psoriasis*;
Self-Assessment
- From:Korean Journal of Dermatology
1993;31(2):217-223
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We have already shown that a new vitamin D3 analogue, calcipotriol is a potent growth inhibitor for human keratinocytes, indicating the close relationship between the in vitro inhibitory effect of calciipotriol and its therapeutic effectiveness or psoriasis. OBJECTIVE: Our purpose was to evaluste the clinical efficscy, safety and tolerability of calcipotriol (50ug/g) ointment twice daily in the treatment of psoriasis. MEHTODS: We treated 31 patients with calcipotriol for 6 weeks. Patients were provided with a maximum of 100g of ointment per week. Efficacy, as measured by the Psoriasis Area and Severity Index(PASI), and safety were assessed at 2,4, and 6 weeks. RESULTS: Reduction of PASI was stastistically significant at all time points for treatments (p<0.01). At the completian of 6 weeks of treatment, the mean PASI reduction was 3.61. An analysis of patient overall self-assessment, at 6 weeks showed clearance or marked improvement in 61%. Some patients developed minimal irriltation of lesional or perilesional skin(6.5%). Laboratory tests did not show any significant changes, in particular there was no change in serum calcium levels. CONCLUSIONS: Calcipotriol ointment was effective as measured by the PASI and the self-assessment in patients with psoriaeis. This treatrnent was well tolerated.
