Recurrent Eosinophilic Pneumonia Associated with Mesalazine Suppository in a Patient with Ulcerative Colitis
10.4166/kjg.2019.73.4.225
- Author:
Myoungrin PARK
1
;
Junguee LEE
;
Sang Bum KANG
;
Yeonhee PARK
Author Information
1. Department of Internal Medicine, VHS Daejeon Hospital, Daejeon, Korea.
- Publication Type:Case Report
- Keywords:
Mesalazine;
Mesalamine;
Suppositories;
Eosinophilic pneumonia;
Pulmonary eosinophilia
- MeSH:
Adult;
Colitis, Ulcerative;
Eosinophils;
Female;
Humans;
Mesalamine;
Pulmonary Eosinophilia;
Recurrence;
Suppositories;
Ulcer
- From:The Korean Journal of Gastroenterology
2019;73(4):225-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mesalazine suppositories are widely used to treat ulcerative colitis and have a guaranteed safety profile, but although rare, they can cause pulmonary toxicity. A 35-year-old woman with ulcerative colitis was diagnosed to have acute eosinophilic pneumonia after 29 days of oral mesalazine use and improved after mesalazine and corticosteroid were withdrawn. Reintroduction of mesalazine suppositories resulted in acute eosinophilic pneumonia recurrence after 28 days. Mesalazine re-administration (even via a different route) in patients with a history of mesalazine-induced eosinophilic pneumonia should be undertaken cautiously, because eosinophilic pneumonia may recurrence.
