A case of neuroblastoma with multiple skin metastases.
- Author:
Koo Il SEO
;
Seung Yong JUNG
;
Kyu Han KIM
;
Jai IL YOUN
;
Yoo Shin LEE
;
Hyo Seop AHN
- Publication Type:Original Article
- Keywords:
Neuroblastoma;
skin metastasis;
immunohistochemical staining;
Neuron specific enolase;
neurofilament protein
- MeSH:
Abdomen;
Basophils;
Drug Therapy;
Female;
Humans;
Infant;
Mitosis;
Neoplasm Metastasis*;
Neuroblastoma*;
Phosphopyruvate Hydratase;
Recurrence;
Rosette Formation;
Scalp;
Skin*
- From:Korean Journal of Dermatology
1993;31(2):264-268
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of neuroblastoma with multiple skin metastases as a chief complaint in a 2-month-old girl. the skin lesions were rnultiple, pea-sized, bluish, nontender, moable subcutaneous nodules on abdomen, back and scalp. Histopathology showed small round or poly gonal tumor cells which have deeply stained, basophilic, hyperchromatic nuclei with some mitoses. Th.se tumor cells showed clumping tendency which is one of early menifestations of rosette formation. Immunohistochemically positive reaction was demonstrated by anti-NSE(neuron specific enolase) antilody but negative reaction by anti-NFP (neurofilament proteiin ) antibody. She has been succesfully treated with combined chemotherapy for 10 months without relapse.
