The Correlations among Depressive Symptoms, Cognitive Performance and Serum BDNF Levels in the Patients with Chronic Kidney Disease
- Author:
Jung Goo LEE
1
;
Min Kyung PARK
;
Yeong Hoon KIM
;
Yang Wook KIM
;
Kyubok JIN
;
Sung Woo PARK
;
Mi Kyoung SEO
;
Young Hoon KIM
Author Information
- Publication Type:Original Article
- Keywords: Chronic kidney disease; Depressive symptoms; Cognitive impairment; BDNF
- MeSH: Brain-Derived Neurotrophic Factor; Cognition; Cognition Disorders; Depression; Enzyme-Linked Immunosorbent Assay; Humans; Memory; Renal Insufficiency, Chronic; Verbal Learning
- From:Psychiatry Investigation 2018;15(2):186-192
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: In the current study, we investigated whether there are relations among depressive symptoms, cognitive performance and serum BDNF levels in the patients with chronic kidney disease (CKD). METHODS: Sixty patients with CKD and 65 healthy controls participated. Depressive symptoms were evaluated with Beck depression inventory (BDI) and Hamilton Depression Rating Scale (HDRS). Mini-Mental State Examination included in the Korean version of the Consortium to Establish a Registry for Alzheimer’s disease (MMSE-KC) assessment packet was used for the evaluation of overall cognitive function. To assess memory function, the Korean version of the Hopkins Verbal Learning Test (K-HVLT) was used. BDNF levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit. RESULTS: The CKD patients showed more depressive symptoms when compared with controls. The depressive symptoms and cognitive function were not associated with serum BDNF levels in the CKD patients. CONCLUSION: In the current study, CKD patients had more depressive symptoms when compared controls. However, the serum BDNF levels of CKD patients were not associated with depressive symptoms and cognitive functions. These findings suggested that the serum BDNF levels may not be reflect the cognitive function and depressive mood state in the CKD patients.
