Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling
- Author:
Yueh Ming TAI
1
;
Chih Yuan KO
;
Chen Cheng LIN
;
Yu Yue WAN
;
Jing Yi CHUNG
;
Yia Ping LIU
Author Information
- Publication Type:Original Article
- Keywords: 5HT1A receptors; Isolation-rearing; Prepulse inhibition; Serotonin
- MeSH: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustics; Animals; Motor Activity; Prepulse Inhibition; Rats; Receptor, Serotonin, 5-HT1A; Reflex, Startle; Sensory Gating; Serotonin; Serotonin 5-HT1 Receptor Agonists; Social Control, Formal
- From:Psychiatry Investigation 2018;15(2):193-199
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured with impaired sensorimotor gating ability. We therefore aimed to examine the effects of 5HT1A activation on acoustic startle response (ASR) and prepulse inhibition (PPI) in IR rats in a condition of compromised presynaptic 5-HT functions. METHODS: Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletor, 5,7-DHT. Seven days later rats entered a protocol of 8-OH-DPAT, a 5-HT1A agonist, in which locomotor activity, ASR and PPI and their tissue levels of 5-HT were measured. RESULTS: Our results found that both IR and 5,7-DHT decreased the tissue concentration of 5-HT. IR-induced hyperactivity and gating impairment were unaffected by 5-HT depletion. 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition. CONCLUSION: The integrity of central 5-HT system is important to 5-HT1A-modulated sensorimotor gating in isolation-reared rats.
