Correlation between Cytokine and Chemokine levels and Clinical Severity in Children with Mycoplasma pneumoniae Pneumonia
- Author:
Hee Joung CHOI
1
;
Yeo Hyang KIM
Author Information
- Publication Type:Original Article
- Keywords: Mycoplasma pneumoniae; Pneumonia; Children; Cytokines; Chemokines
- MeSH: Adrenal Cortex Hormones; Blood Sedimentation; C-Reactive Protein; Chemokines; Child; Cytokines; Fever; Humans; Interleukin-10; Interleukin-18; Interleukin-8; Interleukins; L-Lactate Dehydrogenase; Macrophages; Male; Mycoplasma pneumoniae; Mycoplasma; Necrosis; Pneumonia; Pneumonia, Mycoplasma; Retrospective Studies
- From:Pediatric Infection & Vaccine 2019;26(1):51-59
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The aim of this study was to evaluate the relationships between cytokine and chemokine levels and the clinical severity of Mycoplasma pneumoniae pneumonia. METHODS: A retrospective analysis of clinical and laboratory parameters were performed. Serum levels of interleukin (IL)-6, IL-8, IL-10, IL-18, interferon-γ-inducible protein-10 (IP-10), macrophage inflammatory protein-1β, and tumor necrosis factor-α were measured. The severity of patients' clinical course and radiologic findings were also assessed. RESULTS: Seventy-two patients (35 males and 37 females) with a median age of 3.9 years (range, 1–16 years) were enrolled. Patients with lobar pneumonia (n=29) had significantly higher C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and IL-18 values than those with broncho-interstitial pneumonia (n=43). However, the cytokine and chemokine values did not differ between the group that was treated with corticosteroids (n=31) and the one that was not (n=41). The CRP, ESR, lactate dehydrogenase (LDH), IL-18, and IP-10 values showed positive correlations with fever duration prior to admission. The CRP and ESR values were positively correlated with IL-18, and LDH, with IP-10 levels. CONCLUSIONS: CRP, ESR, LDH, IL-18, and IP-10 values were associated with the severity of the disease, manifesting lobar pneumonia or prolonged fever duration prior to admission.