Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications
10.14776/piv.2018.25.1.50
- Author:
David Chun Ern NG
1
;
L Alexis ANAND
;
Fu Lung KHIU
;
Kah Kee TAN
Author Information
1. Department of Pediatric, Tuanku Ja'afar Hospital, Seremban, Malaysia. davidngce@gmail.com
- Publication Type:Case Report
- Keywords:
Panton-Valentine leukocidin;
Staphylococcus aureus;
Child
- MeSH:
Child;
Humans;
Leukocidins;
Methicillin Resistance;
Staphylococcus aureus;
Staphylococcus;
Virulence Factors
- From:Pediatric Infection & Vaccine
2018;25(1):50-53
- CountryRepublic of Korea
- Language:English
-
Abstract:
Staphylococcus aureus is a well-recognized human pathogen that causes a wide range of infections as a result of its extensive virulence factors. One of these factors is Panton-Valentine leukocidin (PVL), a potent pore-forming cytotoxin that has been linked to invasive S. aureus infections. PVL is one of the important virulence factors for S. aureus and has been largely recognized as one of the markers for community-acquired methicillin-resistant S. aureus. However, the presence of PVL in methicillin-susceptible S. aureus infections is not widely reported in the literature. Thrombotic sequelae of S. aureus infections associated with PVL expression are uncommon in children. We hereby report two children with thrombotic complications associated with PVL-producing methicillin-susceptible S. aureus. Both patients responded well to antibiotic and anticoagulant therapies, and survived without any long-term sequelae.
