Diagnosis of an indistinct Leydig cell tumor by positron emission tomography-computed tomography
10.5468/ogs.2019.62.3.194
- Author:
Jinkyoung KONG
1
;
Yoo Mee PARK
;
Young Sik CHOI
;
SiHyun CHO
;
Byung Seok LEE
;
Joo Hyun PARK
Author Information
1. Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. beanpearl@yuhs.ac
- Publication Type:Case Report
- Keywords:
Sertoli-Leydig cell tumor;
PET-CT;
Diagnosis
- MeSH:
Dehydroepiandrosterone;
Diagnosis;
Electrons;
Female;
Follow-Up Studies;
Hirsutism;
Humans;
Hysterectomy;
Leydig Cell Tumor;
Middle Aged;
Ovary;
Plasma;
Sertoli-Leydig Cell Tumor;
Testosterone;
Virilism;
Voice
- From:Obstetrics & Gynecology Science
2019;62(3):194-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 51-year-old perimenopausal female patient presented with hirsutism and voice thickening which was started approximately one and a half years ago. Her initial hormone assay revealed elevated plasma testosterone, 5a-dihydrotestosterone, and dehydroepiandrosterone (DHEA) levels and therefore androgen-secreting tumor was first suspected. However, the lesion was inconspicuous on transvaginal sonography, abdominal-pelvic computed tomography (CT) scan, and pelvic magnetic resonance (MRI) imaging. Consequently, 18F-fluorodeoxyglucose (FDG) positron emission tomography-CT was performed, which localized the lesion as a focal FDG uptake within the right adnexa. Total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was performed, and although visible gross mass lesions were not observed intraoperatively, pure Leydig cell tumor was pathologically confirmed within the right ovary. Plasma testosterone, 5a-dihydrotestosterone, and DHEA levels were normalized postoperatively. Clinical signs of virilization were also significantly resolved after 3-months of follow-up.
