Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery?
- Author:
Seung Ho LEE
1
;
Kyoung Joo CHO
;
Mi Hyang KO
;
Hyun Yee CHO
;
Kwang Beom LEE
;
Soyi LIM
Author Information
- Publication Type:Original Article
- Keywords: Uterine cervical neoplasms; Hysterectomy
- MeSH: Cohort Studies; Gynecology; Humans; Hysterectomy; Lymph Node Excision; Lymph Nodes; Multivariate Analysis; Obstetrics; Retrospective Studies; Uterine Cervical Neoplasms
- From:Obstetrics & Gynecology Science 2018;61(1):88-94
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery. METHODS: We retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer. RESULTS: Overall, 18 (15.0%) patients had parametrial tumor involvement. Tumor size larger than 2 cm, invasion depth greater than 1 cm, presence of lymphovascular space involvement (LVSI), corpus involvement, and positive lymph nodes were statistically associated with parametrial involvement. Multivariate analysis for other factors showed invasion depth >1 cm (P=0.029), and corpus involvement (P=0.022) were significantly associated with parametrial involvement. A subgroup with tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. CONCLUSION: Tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. Invasion depth >1 cm and corpus involvement were significantly associated with parametrial involvement in multivariate analysis. These finding may suggest that tumor size may a strong predictor of parametrial involvement in International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, which can be used to select a subgroup population for less radical surgery.