Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case
10.5468/ogs.2018.61.1.165
- Author:
Chul Min PARK
1
;
Hyun Min KOH
;
Soyun PARK
;
Hye Sim KANG
;
Soon Sup SHIM
;
Sung Yob KIM
Author Information
1. Department of Obstetrics and Gynecology, Jeju National University Hospital, Jeju, Korea. obgymd@gmail.com
- Publication Type:Case Report
- Keywords:
Adenocarcinoma;
Mucinous;
Gastric type;
Human papillomavirus
- MeSH:
Adenocarcinoma;
Cervix Uteri;
Diagnosis, Differential;
DNA;
Female;
Humans;
Immunohistochemistry;
Mucins;
Recurrence
- From:Obstetrics & Gynecology Science
2018;61(1):165-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastric type mucinous endocervical adenocarcinomas of the uterine cervix (GAC) are a newly classified mucinous subtype with morphologically in 2014, WHO. They have a much more aggressiveness and show unusual metastatic patterns compared to usual type endocervical adenocarcinoma. They tend to present at higher stage and even in stage I, they have worse survival. Therefore, differential diagnosis of GAC from the usual type of endocervical adenocarcinoma is very important because they are related to a significant risk of recurrence and decreased 5-year disease-specific survival. Besides, GACs are mostly not associated with human papillomavirus (HPV) infection and p16 immunohistochemistry is also typically negative in GAC that is HPV-unassociated tumor. We report a very rare and interesting case of stage IB1 GAC with negative HPV DNA and p16.