Predictors of Neurodevelopmental Outcomes in Newborns Undergoing Hypothermia Therapy
- Author:
Min Kyo CHUN
1
;
Hyun Jung SUNG
;
Joo Hyung PARK
;
Gye Yeon LIM
;
So Young KIM
Author Information
- Publication Type:Original Article
- Keywords: Newborn; Hypoxia-ischemia, brain; Hypothermia treatment; Magnetic resonance imaging; Treatment outcome; Risk factors
- MeSH: Asphyxia; Brain; Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Intensive Care, Neonatal; Korea; Leukocytes; Logistic Models; Magnetic Resonance Imaging; Medical Records; Risk Factors; Treatment Outcome
- From:Neonatal Medicine 2019;26(1):17-23
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: This study aimed to identify the early predictors of neurodevelopmental outcomes in infants undergoing therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy. METHODS: The medical records of 24 neonates who underwent hypothermia therapy for hypoxic ischemic encephalopathy at the neonatal intensive care unit of Yeouido St. Mary's Hospital of the Catholic University of Korea between August 2013 and May 2016 were reviewed. Patients were divided into two groups according to their neurological outcome at the age of 18 to 24 months: a normal group (n=14), which included patients with normal neurological function, and an abnormal group (n=10), which included patients with neurological deficits. The clinical characteristics, clinical outcomes, and laboratory findings before and after hypothermia treatment were compared between the groups. RESULTS: There were no significant differences in the demographic characteristics between the two groups. With regard to clinical outcomes, only brain magnetic resonance imaging (MRI) findings showed significant differences between the normal and abnormal groups (21.4% vs. 100.0%, P < 0.001). With regard to laboratory findings, there were significant differences in the white blood cell (WBC) count after hypothermia treatment between the normal and abnormal groups (9.78±3.52 vs. 14.90±3.48, P=0.003). However, logistic regression analysis showed that the WBC count was not an independent risk factor for abnormal neurodevelopment (P>0.05). CONCLUSION: The presence of abnormal lesions on MRI was the most useful predictor of poor neurodevelopmental outcome in infants treated with therapeutic hypothermia after perinatal asphyxia.
