Comparison of Clinical Factors and Neurodevelopmental Outcomes between Early- and Late-Onset Periventricular Leukomalacia in Very Low Birth Weight Infants
- Author:
Mihye BAE
1
;
Narae LEE
;
Young Mi HAN
;
Kyung Hee PARK
;
Shin Yun BYUN
Author Information
- Publication Type:Original Article
- Keywords: Leukomalacia, periventricular; Fetal membranes, premature rupture; Infant, very low birth weight
- MeSH: Apgar Score; Diagnosis; Female; Fetal Membranes, Premature Rupture; Humans; Incidence; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Intensive Care, Neonatal; Leukomalacia, Periventricular; Membranes; Pregnancy; Retrospective Studies; Rupture; Tocolysis; Weights and Measures
- From:Neonatal Medicine 2019;26(1):48-54
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: To analyze and compare the clinical factors and neurodevelopmental outcomes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI). METHODS: We performed a retrospective study involving 199 newborn infants weighing < 1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the clinical factors and neurodevelopmental outcomes between the groups. RESULTS: The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observed in neurodevelopmental outcomes between the early- and late-onset PVL groups. CONCLUSION: Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.
