Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience
- Author:
Yong Hoon CHO
1
;
Soo Hong KIM
;
Hae Young KIM
;
Young Mi HAN
;
Na Rae LEE
;
Mi Hye BAE
;
Kyung Hee PARK
;
Shin Yun BYUN
Author Information
- Publication Type:Original Article
- Keywords: Abdominoperineal; Solid tumor; Newborn
- MeSH: Follow-Up Studies; Gestational Age; Hepatoblastoma; Humans; Infant, Newborn; Mortality; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Parturition; Recurrence; Retrospective Studies; Sacrococcygeal Region
- From:Neonatal Medicine 2018;25(1):23-28
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. METHODS: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (≤28 days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. RESULTS: The mean gestational age and postnatal age at the time of operation were 38.3±1.8 weeks and 13.5±8.3 days, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was 6.4×5.3 cm (3.5–17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean 66.4±44.2 months). CONCLUSION: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.
