Cytotoxic Lactones from the Pericarps of Litsea japonica
10.20307/nps.2019.25.1.23
- Author:
Quynh Mai Thi NGO
1
;
Thao Quyen CAO
;
Mi Hee WOO
;
Byung Sun MIN
Author Information
1. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. bsmin@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Litsea japonica;
Lauraceae;
butanolide;
lactone;
cytotoxic activity;
apoptosis
- MeSH:
Apoptosis;
Cell Line;
Lactones;
Lauraceae;
Litsea;
MCF-7 Cells
- From:Natural Product Sciences
2019;25(1):23-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
From the pericarps of Litsea japonica (Thunb.) Jussieu, eighteen butanolide derivatives (1 – 18) were evaluated for their cytotoxic activity against HeLa, HL-60, and MCF-7 cells. Compounds 1 – 9 with 2-alkylidene-3-hydroxy-4-methylbutanolides structure exhibited cytotoxic activities against cancer-cell lines. Among them, compound 8 (litsenolide D₂) exhibited the most potent cytotoxicity against the tested cell lines, including HeLa, HL-60, and MCF-7, with IC₅₀ values of 17.6 ± 1.3, 4.2 ± 0.2, and 12.8 ± 0.0 µM, respectively. Compound 8 induced apoptosis in a dose-dependent manner. Annexin V/Propidium Iodide (PI) double staining confirmed that 8 effectively induced apoptosis in MCF-7 cells. To the best of our knowledge, we have reported cytotoxic activity of butanolides from L. japonica against these cancer-cell lines for the first time.
