Isolation of Constituents with Nitric Oxide Synthase Inhibition Activity from Phryma leptostachya var. asiatica
10.20307/nps.2019.25.1.34
- Author:
Donghwa KIM
1
;
Sang Kook LEE
;
Kyoung Sik PARK
;
Na Yun KWON
;
Hee Juhn PARK
Author Information
1. College of Pharmacy, Seoul National University, Seoul 08826, Korea.
- Publication Type:Original Article
- Keywords:
Phryma leptostachya var. asiatica;
Phyrymaceae;
nitric oxide;
anti-inflammatory;
ursolic acid
- MeSH:
Macrophages;
Nitric Oxide Synthase;
Nitric Oxide;
Plants
- From:Natural Product Sciences
2019;25(1):34-37
- CountryRepublic of Korea
- Language:English
-
Abstract:
Phytochemical studies were performed to identify the active principles of Phryma leptostachya var. asiatica (Phyrymaceae) for anti-inflammation. The anti-inflammatory activity was assessed by measuring the inhibition rate on nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells. Of the five compounds including ursolic acid, phrymarolin I, harpagide, haedoxancoside A, and acteoside isolated from this plant, ursolic acid showed the most prominent inhibition of NO formation. Therefore, ursolic acid may be the anti-inflammatory principle of Phryma leptostachya var. asiatica.
