Hematopoiesis Activity of Sambucus javanica on Chloramphenicol-induced Aplastic Anemia Mouse Model
10.20307/nps.2019.25.1.59
- Author:
Wira Eka PUTRA
1
;
Muhaimin RIFA'I
Author Information
1. Department of Biology, Faculty of Mathematics and Natural Sciences, State University of Malang, Indonesia. wep.cendekia@gmail.com
- Publication Type:Original Article
- Keywords:
Aplastic anemia;
CMP;
hematopoiesis;
medicinal plant;
S. javanica
- MeSH:
Anemia, Aplastic;
Animals;
B-Lymphocytes;
Bone Marrow;
Chloramphenicol;
Erythrocytes;
Flow Cytometry;
Fruit;
Granulocytes;
Hematopoiesis;
Homeostasis;
Immunosuppression;
Iron;
Mice;
Plants, Medicinal;
Sambucus;
Stem Cell Transplantation;
Stem Cells
- From:Natural Product Sciences
2019;25(1):59-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hematopoiesis has a pivotal role in the maintenance of body homeostasis. Ironically, several hematological disorder caused by chemicals, drugs, and other environmental factors lead to severe bone marrow failure. Current treatments like stem cell transplantation and immunosuppression remain ineffective to ameliorate this diseases. Therefore, a newtreatment to overcome this entity is necessary, one of them by promoting the usage of medicinal plants. Thus, this study aimed to evaluate the hematopoiesis potency of S. javanica berries and leaves extracts in chloramphenicol (CMP)-induced aplastic anemia mice model. In this present study, several types of blood progenitor cell such as TER-119⁺VLA-4⁺ erythrocytes lineage, Gr-1⁺ granulocytes, and B220⁺ B-cell progenitor cells were evaluated by flow cytometry analysis. Accordingly, we revealed that S. javanica berries and leaves extracts significantly promoted TER-119⁺VLA-4⁺ erythrocytes lineage and Gr-1⁺ granulocytes after exposed by CMP. Thus, these results suggested that S. javanica berries and leaves extracts might have hematopoiesis activity in CMP-induced aplastic anemia mice model.
