Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells
10.20307/nps.2019.25.1.72
- Author:
Eunae KIM
1
;
Hyun Jung KIM
;
Ha Na OH
;
Ah Won KWAK
;
Su Nam KIM
;
Bok Yun KANG
;
Seung Sik CHO
;
Jung Hyun SHIM
;
Goo YOON
Author Information
1. College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Asarum sieboldii;
Cytotoxicity;
Breast cancer;
Xanthoxylol
- MeSH:
Asarum;
Breast Neoplasms;
Breast;
Humans;
In Vitro Techniques
- From:Natural Product Sciences
2019;25(1):72-75
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC₅₀ values of 9.15 and 13.95 µM, respectively.
