Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata
10.20307/nps.2018.24.4.284
- Author:
Mulyadi TANJUNG
1
;
Intan NURMALASARI
;
Aisyah Kanti WILUJENG
;
Ratih Dewi SAPUTRI
;
Fida RACHMADIARTI
;
Tjitjik Srie TJAHJANDARIE
Author Information
1. Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia. mulyadi-t@fst.unair.ac.id
- Publication Type:Original Article
- Keywords:
Acronyculatin P;
isoprenylated acetophenone;
Acronychia pedunculata;
P-388 cells
- MeSH:
Leukemia;
Rutaceae;
Thoracica
- From:Natural Product Sciences
2018;24(4):284-287
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3′,5′-diisoprenyl-2′,4′-dihydroxy-6′-methoxyphenylethanone (2) and 3′-isoprenyl-2′,4′,6′-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with IC₅₀ 15.42 µM.
