Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines
10.20307/nps.2018.24.4.293
- Author:
Mi Gyeong JANG
1
;
Hee Chul KO
;
Se Jae KIM
Author Information
1. Jeju Sasa Industry Development Agency, Jeju National University, 102 Jejudaehakno, Jeju-si Special Self-Governing Province 63243, Korea. sjkim@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Apoptosis;
p-coumaric acid;
phytochemicals;
Sasa quelpaertensis Nakai
- MeSH:
Amino Acids;
Apoptosis;
Caspase 3;
Cell Line;
HL-60 Cells;
Humans;
Phytochemicals;
Polyphenols;
Polysaccharides;
Sasa;
Water
- From:Natural Product Sciences
2018;24(4):293-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.