Meliglabrin, A New Flavonol Derivative from the leaves of Melicope glabra (Blume) T.G. Hartley
10.20307/nps.2018.24.3.155
- Author:
Ratih Dewi SAPUTRI
1
;
Tjitjik SRIE TJAHJANDARIE
;
Mulyadi TANJUNG
Author Information
1. Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia. mulyadi-t@fst.unair.ac.id
- Publication Type:Original Article
- Keywords:
Meliglabrin;
flavonol, Melicope glabra, P-388 cells
- MeSH:
Flavonols;
Leukemia;
Rutaceae
- From:Natural Product Sciences
2018;24(3):155-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4′-dihydroxy-3,7,3′-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 – 4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.