Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells
10.20307/nps.2018.24.3.194
- Author:
Nguyen Phuong THAO
1
;
Young Suk LEE
;
Bui Thi Thuy LUYEN
;
Ha Van OANH
;
Irshad ALI
;
Madeeha AROOJ
;
Young Sang KOH
;
Seo Young YANG
;
Young Ho KIM
Author Information
1. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Hanoi, Vietnam.
- Publication Type:Original Article
- Keywords:
Cimicifuga dahurica;
Ranunculaceae;
Anti-inflammatory;
IL-12 p40;
IL-6,TNF-α
- MeSH:
Alzheimer Disease;
Arthritis, Rheumatoid;
Cardiovascular Diseases;
Cimicifuga;
Cytokines;
Dendritic Cells;
Immune System;
In Vitro Techniques;
Inflammation;
Interleukin-6;
Interleukins;
Korea;
Primary Cell Culture;
Ranunculaceae;
Tumor Necrosis Factor-alpha
- From:Natural Product Sciences
2018;24(3):194-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
Inflammation is a biological response caused by overactivation of the immune system and is controlled by immune cells via a variety of cytokines. The overproduction of pro-inflammatory cytokines enhances abnormal host immunity, resulting in diseases such as rheumatoid arthritis, cardiovascular disease, Alzheimer's disease, and cancer. Inhibiting the production of pro-inflammatory cytokines such as interleukin (IL)-12p40, IL-6, and tumor necrosis factor (TNF)-α might be one way to treat these conditions. Here, we investigated the anti-inflammatory activity of compounds isolated from Cimicifuga dahurica (Turcz.) Maxim., which is traditionally used as an antipyretic and analgesic in Korea. In primary cell culture assays, 12 compounds were found to inhibit the production of pro-inflammatory cytokines (IL-12p40, IL-6, and TNF-α) in vitro in bone marrow-derived dendritic cells stimulated with LPS.
