Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
10.20307/nps.2018.24.2.88
- Author:
Kooi Yeong KHAW
1
;
Vikneswaran MURUGAIYAH
;
Melati KHAIRUDDEAN
;
Wen Nee TAN
Author Information
1. Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
- Publication Type:Original Article
- Keywords:
Garcinia atroviridis;
Garcinexanthone G;
Butyrylcholinesterase;
Molecular docking
- MeSH:
Butyrylcholinesterase;
Catalytic Domain;
Cholinesterase Inhibitors;
Cholinesterases;
Computer Simulation;
Drug Design;
Garcinia;
Hydrogen Bonding;
In Vitro Techniques;
Quercetin;
Xanthones
- From:Natural Product Sciences
2018;24(2):88-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in silico. The in vitro cholinesterase results showed that quercetin (3) was the most active AChE inhibitor (12.65 ± 1.57 µg/ml) while garcinexanthone G (6) was the most active BChE inhibitor (18.86 ± 2.41 µg/ml). It is noteworthy to note that compound 6 was a selective inhibitor with the selectivity index of 11.82. Molecular insight from docking interaction further substantiate that orientation of compound 6 in the catalytic site which enhanced its binding affinity as compared to other xanthones. The nature of protein-ligand interactions of compound 6 is mainly hydrogen bonding, and the hydroxyl group of compound 6 at C-10 is vital in BChE inhibition activity. Therefore, compound 6 is a notable lead for further drug design and development of BChE selective inhibitor.
