Cytotoxic Triterpenoids from the Fruits of Ligustrum japonicum
10.20307/nps.2018.24.2.93
- Author:
Quynh Mai Thi NGO
1
;
Thao Quyen CAO
;
Mi Hee WOO
;
Byung Sun MIN
;
Kwon Yeon WEON
Author Information
1. College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. bsmin@cu.ac.kr, weonky@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Ligustrum japonicum;
Oleaceae;
Triterpenoids;
Cytotoxic activity
- MeSH:
Antineoplastic Agents;
Fruit;
HL-60 Cells;
Humans;
Inhibitory Concentration 50;
Ligustrum;
Mass Screening;
Nerium;
Oleaceae;
Phytochemicals;
Plants, Medicinal
- From:Natural Product Sciences
2018;24(2):93-98
- CountryRepublic of Korea
- Language:English
-
Abstract:
Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 – 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC50 values of 5.5 µM, and moderate effects on HL-60 cells with IC₅₀ values of 55.9 µM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with IC₅₀ value of 55.0 and 68.8 µM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with IC₅₀ value of 63.9 µM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.
