Phytochemical Constituents of Capsella bursa-pastoris and Their Anti-inflammatory Activity
10.20307/nps.2018.24.2.132
- Author:
Joon Min CHA
1
;
Dong Hyun KIM
;
Tae Hyun LEE
;
Lalita SUBEDI
;
Sun Yeou KIM
;
Kang Ro LEE
Author Information
1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea. krlee@skku.edu
- Publication Type:Original Article
- Keywords:
Capsella bursa-pastoris;
Cruciferae;
Sulfur compound
- MeSH:
Brassicaceae;
Capsella;
Inhibitory Concentration 50;
Luteolin;
Microglia;
Nitric Oxide;
Plants
- From:Natural Product Sciences
2018;24(2):132-138
- CountryRepublic of Korea
- Language:English
-
Abstract:
Phytochemical investigation of 80% MeOH extract of the aerial parts of Capsella bursa-pastoris yielded fourteen compounds (1 – 14). The structures of the compounds were elucidated by spectroscopic methods to be methyl-1-thio-β-D-glucopyranosyl disulfide (1), 10-methylsulphinyl-decanenitrile (2), 11-methyl-sulphinyl-undecanenitrile (3), 1-O-(lauroyl)glycerol (4), phytene-1, 2-diol (5), (3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one (6), loliolide (7), β-sitosterol (8), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone (9), 1-feruloyl-β-D-glucopyranoside (10), pinoresinol-4′-O-β-D-glucopyranoside (11), luteolin (12), quercetin-3-O-β-D-glucopyranoside (13), and luteolin 6-C-β-glucopyranoside (14). Although compound 1 was reported as synthetic compound, 1 was first isolated from natural source. NMR spectral data assignments of 1, 2 and 3 were reported for the first time, and compounds 1 – 14 were for the first time reported from this plant source. The anti-inflammatory effects of 1 – 14 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 12 exhibited strong inhibitory effects on nitric oxide production in LPS-activated BV-2 cells with IC50 values of 9.70 µM.
