A Conformational Isomer of Soulattrolide from the Stem Bark of Calophyllum symingtonianum and Its Antibacterial Activity
10.20307/nps.2018.24.1.47
- Author:
Deny SUSANTI
1
;
Nissad ATTOUMANI
;
Muhammad TAHER
;
Mohd Fazlin REZALI
;
Md Hossain SOHRAB
;
Choudhury Mahmood HASAN
;
Zainul AMIRUDDIN ZAKARIA
Author Information
1. Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
- Publication Type:Original Article
- Keywords:
Calophyllum symingtonianum;
Guttiferae;
Coumarins;
Antibacterial
- MeSH:
Bacillus cereus;
Calophyllum;
Coumarins;
Diarrhea;
Escherichia coli;
Flowers;
Forests;
Malaysia;
Mass Spectrometry;
Pseudomonas aeruginosa;
Rheumatic Diseases;
Silica Gel;
Staphylococcus aureus;
Trees
- From:Natural Product Sciences
2018;24(1):47-53
- CountryRepublic of Korea
- Language:English
-
Abstract:
Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 µg/ml MIC value. Compound 2 also inhibits S. aureus with 25 µg/ml MIC value.
