Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study
10.1186/s40902-019-0193-5
- Author:
Jae Young KIM
1
;
Dae Hoon KIM
;
Hyo Won JANG
;
Kwang Ho PARK
;
Jong Ki HUH
Author Information
1. Department of Oral and Maxillofacial Surgery, Gangnam Severance Hospital, Yonsei University College of Dentistry, 211 Eonju-ro, Gangnam-gu, Seoul, 06273 South Korea. omshuh@yuhs.ac.
- Publication Type:Original Article
- Keywords:
Bisphosphonate;
Botulinum toxin;
Mandibular condyle;
Temporomandibular joint
- MeSH:
Animals;
Bone Diseases, Metabolic;
Bone Resorption;
Botulinum Toxins;
Mandibular Condyle;
Masticatory Muscles;
Rats;
Temporomandibular Joint
- From:Maxillofacial Plastic and Reconstructive Surgery
2019;41(1):11-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. RESULTS: The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group. CONCLUSION: Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.
