Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats
10.1186/s40902-018-0146-4
- Author:
Hyun SEOK
1
;
Seong Gon KIM
;
Min Keun KIM
;
Insan JANG
;
Janghoon AHN
Author Information
1. Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju, 28644 South Korea.
- Publication Type:Original Article
- Keywords:
Botulinum toxin A;
Masseter muscle;
Mandible;
Growth
- MeSH:
Animals;
Bone Development;
Botulinum Toxins;
Botulinum Toxins, Type A;
Formaldehyde;
Mandible;
Masseter Muscle;
Masticatory Muscles;
Rats;
Rats, Sprague-Dawley;
Skull
- From:Maxillofacial Plastic and Reconstructive Surgery
2018;40(1):5-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. METHODS: Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis. RESULTS: The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side. CONCLUSION: BTX-A injection into the masseter muscle influences mandibular bone growth.
