Evaluation of the efficacy of an attenuated live vaccine based on virulent porcine reproductive and respiratory syndrome virus 2 in young pigs
10.14405/kjvr.2018.58.3.137
- Author:
Seung Chul LEE
1
;
Yun Hee NOH
;
Sunhee LEE
;
Hwan Won CHOI
;
In Joong YOON
;
Shien Young KANG
;
Changhee LEE
Author Information
1. Choong Ang Vaccine Laboratories Co., Ltd., Daejeon 34055, Korea.
- Publication Type:Brief Communication
- Keywords:
attenuated vaccines;
porcine reproductive and respiratory syndrome virus;
treatment outcome;
vaccination
- MeSH:
Animals;
Immunization;
Lung;
Lymph Nodes;
Porcine Reproductive and Respiratory Syndrome;
Porcine respiratory and reproductive syndrome virus;
Swine;
Treatment Outcome;
Vaccination;
Vaccines, Attenuated;
Viremia
- From:Korean Journal of Veterinary Research
2018;58(3):137-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
The efficacy of the CA-2-MP120 vaccine, a cell culture-attenuated strain of virulent porcine reproductive and respiratory syndrome virus (PRRSV), was assessed in pigs. Despite the persistence of viremia in all vaccinated animals during the immunization period, the virus was not detected in vaccinated pigs following challenge. Furthermore, no pigs in the vaccinated group shed PRRSV nasally, orally or rectally throughout the experiment. Moreover, histopathological lung and lymph node lesions in the immunized group were much milder than those in the unimmunized and challenged group. These results indicated that CA-2-MP120 can provide effective protection against virulent wildtype PRRSV-2.
