Clinical management of suspected intracranial meningioma in three dogs with pulsed high-dose hydroxyurea
10.14405/kjvr.2018.58.2.103
- Author:
Jae Geum CHO
1
;
Kun Ho SONG
;
Kyoung Won SEO
Author Information
1. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea. kwseo@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
brain neoplasms;
chemotherapy;
hydroxyurea;
meningioma;
seizures
- MeSH:
Animals;
Ataxia;
Brain Neoplasms;
Dogs;
Drug Therapy;
Head;
Hydroxyurea;
Magnetic Resonance Imaging;
Meningioma;
Neurologic Manifestations;
Recurrence;
Seizures
- From:Korean Journal of Veterinary Research
2018;58(2):103-106
- CountryRepublic of Korea
- Language:English
-
Abstract:
Three aged dogs, all over 15 years old, with multiple seizure events and various neurologic signs such as head turn and ataxia were brought to the referring hospital. Two cases were tentatively diagnosed with intracranial meningioma based on magnetic resonance imaging, and one case was histopathologically confirmed as meningioma at necropsy. All dogs improved after initiation of pulsed high-dose hydroxyurea (HU) treatment. Clinical sign relapses were managed by repeating high-dose HU without obvious side effects. Pulsed high-dose HU can be applied when clinical signs are refractory to the traditionally recommended dosage for intracranial meningioma in dogs.
