A Higher Ratio of Serum Calcium to Magnesium Is Associated With Aggressive Clinicopathological Characteristics in the Patients Who Underwent Radical Prostatectomy
10.22465/kjuo.2018.16.1.25
- Author:
Sang Won KIM
1
;
You Jin LEE
;
Jae Wook CHUNG
;
Yun Sok HA
;
Seock Hwan CHOI
;
Jun Nyung LEE
;
Bum Soo KIM
;
Hyun Tae KIM
;
Tae Hwan KIM
;
Eun Sang YOO
;
Tae Gyun KWON
Author Information
1. Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea. ht-kim1212@hanmail.net
- Publication Type:Multicenter Study
- Keywords:
Calcium;
Magnesium;
Prostatic neoplasms
- MeSH:
Calcium;
Cell Proliferation;
Follow-Up Studies;
Humans;
Logistic Models;
Magnesium;
Neoplasm Grading;
Prospective Studies;
Prostate-Specific Antigen;
Prostatectomy;
Prostatic Neoplasms;
Retrospective Studies
- From:Korean Journal of Urological Oncology
2018;16(1):25-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Changes in magnesium (Mg) concentration and calcium-to-magnesium ratio (Ca/Mg) play a critical role in cancer cell proliferation. In this study, we evaluated the association between preoperative Ca/Mg ratio and clinicopathological characteristics of prostate cancer. MATERIALS AND METHODS: Preoperative serum levels of Ca and Mg, as well as the Ca/Mg ratio, were retrospectively analyzed in 319 consecutive patients with prostate cancer who underwent radical prostatectomy at our institution between February 2014 and June 2016. Blood Ca and Mg levels, together with the Ca/Mg ratio, were analyzed in relation to the patients' demographic and clinicopathological characteristics. RESULTS: Preoperative Ca/Mg ratio was significantly higher in patients with pathologic Gleason score (pGS)≥8 than in those with pGS≤7 (mean [95% confidence interval]: 4.45 [4.35–4.56] vs. 4.32 [4.27–4.38], p=0.037). The Ca/Mg ratio was positively correlated with preoperative prostate-specific antigen (PSA) levels (r=0.116, p=0.039) and PSA density (r=0.156, p=0.005). Ca/Mg ratio was a preoperative predictor of high pGS (≥8) according to multiple logistic regression analysis (odds ratio, 1.752; 95% confidence interval, 1.002–3.064; p=0.049). CONCLUSIONS: A high serum Ca/Mg ratio was closely associated with worse clinicopathological parameters (high PSA and PSA density and pGS≥8), suggesting that the Ca/Mg ratio may be a useful serological marker for further characterization of oncologic features in prostate cancer. A multicenter prospective study with long-term follow-up is recommended to further assess the utility of this cost-effective marker as a prognostic indicator of prostate cancer.
