Long-Lasting Antiandrogen Withdrawal Syndrome in Castration-Resistant Prostate Cancer: Three Cases With Complete Response
10.22465/kjuo.2018.16.1.38
- Author:
Sang Jin KIM
1
;
Jae Hyun RYU
;
Yun Beom KIM
;
Tae Young JUNG
Author Information
1. Department of Urology, Veterans Health Service Medical Center, Seoul, Korea. urodoct@hotmail.com
- Publication Type:Case Report
- Keywords:
Androgen antagonists;
Androgen deprivation therapy;
Antiandrogen withdrawal syndrome;
Castration resistant prostatic neoplasms;
Complete response
- MeSH:
Androgen Antagonists;
Humans;
Prostate;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Prostatic Neoplasms, Castration-Resistant
- From:Korean Journal of Urological Oncology
2018;16(1):38-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is a case report of 3 patients who had a dramatic and long-term complete response after antiandrogen withdrawal. All 3 patients were diagnosed with advanced or metastatic prostate cancer with a high prostate-specific antigen (PSA) level. For all patients, we started combined androgen blockade as androgen deprivation therapy and the PSA concentration decreased to <0.1 ng/mL, but then started to increase. After discontinuation of antiandrogen the PSA concentration decreased again and has remained below the limit of sensitivity for more than 1 year in all 3 patients.
