Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
- Author:
Hyun Min KOH
1
;
Hyo Jung AN
;
Gyung Hyuck KO
;
Jeong Hee LEE
;
Jong Sil LEE
;
Dong Chul KIM
;
Jung Wook YANG
;
Min Hye KIM
;
Sung Hwan KIM
;
Kyung Nyeo JEON
;
Gyeong Won LEE
;
Se Min JANG
;
Dae Hyun SONG
Author Information
- Publication Type:Original Article
- Keywords: S100A8; S100A9; Carcinoma, non-small cell lung; Prognosis
- MeSH: Adenocarcinoma; Calgranulin B; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Lung; Male; Methods; Neoplasm Metastasis; Prognosis; Smoke; Smoking
- From:Journal of Pathology and Translational Medicine 2019;53(1):13-22
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC). METHODS: We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells. RESULTS: The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC. CONCLUSIONS: S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
