PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
- Author:
Ji Hyun LEE
1
;
Hye Ju KANG
;
Chong Woo YOO
;
Weon Seo PARK
;
Jun Sun RYU
;
Yuh Seog JUNG
;
Sung Weon CHOI
;
Joo Yong PARK
;
Nayoung HAN
Author Information
- Publication Type:Original Article
- Keywords: Salivary gland neoplasms; Immunohistochemistry; Pleomorphic adenoma gene-1; SOX transcription factors; Oncogene proteins v-Myb
- MeSH: Adenoma; Adenoma, Pleomorphic; Antibody-Dependent Cell Cytotoxicity; Carcinogenesis; Carcinoma, Adenoid Cystic; Diagnosis; Immunohistochemistry; Oncogene Proteins; Oncogene Proteins v-myb; Parotid Gland; Pathology, Molecular; Salivary Gland Neoplasms; Salivary Glands; SOX Transcription Factors; Translocation, Genetic
- From:Journal of Pathology and Translational Medicine 2019;53(1):23-30
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. METHODS: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Immunohistochemical staining of PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays. RESULTS: Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showed nuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphic adenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary gland neoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors. Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%) malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and one myoepithelial carcinoma with focal AdCC-like histology. CONCLUSIONS: PLAG1 expression is specific to pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor, but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology is unclear in the surgical specimen.
