Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation
- Author:
Haeyon CHO
1
;
Jin Oh CHOI
;
Eun Seok JEON
;
Jung Sun KIM
Author Information
- Publication Type:Original Article
- Keywords: Quilty lesion; Endocardial inflammatory infiltrates; Acute cellular rejection; Cardiac allograft vasculopathy; Heart transplantation
- MeSH: Allografts; Biopsy; Coronary Angiography; Heart Transplantation; Heart; Humans; Medical Records
- From:Journal of Pathology and Translational Medicine 2019;53(1):50-56
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients. METHODS: A total of 1190 EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions, acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy was diagnosed by computed tomography coronary angiography. Clinical information, including the patients’ survival was retrieved by a review of medical records. RESULTS: Eighty-eight patients (75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellular rejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patient sdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesions from transplantation was longer than that of acute cellular rejections. We found a significant association between Quilty lesions and cardiac allograft vasculopathy. No significant relationship was found between Quilty lesions and the patients’ survival. CONCLUSIONS: Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.
