Primary Peripheral Gamma Delta T-Cell Lymphoma of the Central Nervous System: Report of a Case Involving the Intramedullary Spinal Cord and Presenting with Myelopathy
- Author:
Jeemin YIM
1
;
Seung Geun SONG
;
Sehui KIM
;
Jae Won CHOI
;
Kyu Chong LEE
;
Jeong Mo BAE
;
Yoon Kyung JEON
Author Information
- Publication Type:Case Report
- Keywords: Primary central nervous system lymphoma; Primary intramedullary spinal cord lymphoma; Peripheral T-cell lymphoma; γδ T-cell lymphoma
- MeSH: Aged; Back Pain; Brain; Central Nervous System; Cytoplasm; Female; Granzymes; Herpesvirus 4, Human; Humans; Laminectomy; Lateral Ventricles; Lower Extremity; Lymphocytes; Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Magnetic Resonance Imaging; Paraplegia; Skin; Spinal Cord Diseases; Spinal Cord; T-Lymphocytes; White Matter
- From:Journal of Pathology and Translational Medicine 2019;53(1):57-61
- CountryRepublic of Korea
- Language:English
- Abstract: Primary central nervous system lymphoma of T-cell origin (T-PCNSL) is rare, and its clinicopathological features remain unclear. Peripheral T-cell lymphoma of γδ T-cell origin is an aggressive lymphoma mainly involving extranodal sites. Here, we report a case of γδ T-PCNSL involving the intramedullary spinal cord and presenting with paraplegia. A 75-year-old Korean woman visited the hospital complaining of back pain and lower extremity weakness. Magnetic resonance imaging revealed multifocal enhancing intramedullary nodular lesions in the thoracic and lumbar spinal cord. An enhancing nodular lesion was observed in the periventricular white matter of the lateral ventricle in the brain. There were no other abnormalities in systemic organs or skin. Laminectomy and tumor removal were performed. The tumor consisted of monomorphic, medium-to-large atypical lymphocytes with pale-to-eosinophilic cytoplasm. Immunohistochemically, the tumor cells were CD3(+), TCRβF1(-), TCRγ(+), CD30(-), CD4(-), CD8(-), CD56(+), TIA1(+), granzyme B(+), and CD103(+). Epstein-Barr virus in situ was negative. This case represents a unique T-PCNSL of γδ T-cell origin involving the spinal cord.
