Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review
- Author:
Nu Ri JANG
1
;
Dae Hyung LEE
;
Eun Jung JANG
;
Young Kyung BAE
;
Jina BAEK
;
Min Hye JANG
Author Information
- Publication Type:Case Report
- Keywords: Ovarian gynandroblastoma; Juvenile granulosa cell tumor; Ovary; Postmenopause
- MeSH: Abdominal Pain; Adolescent; Aged; Child; Female; Granulosa Cell Tumor; Granulosa Cells; Humans; Hysterectomy; Male; Ovary; Postmenopause; Sex Cord-Gonadal Stromal Tumors
- From:Journal of Pathology and Translational Medicine 2018;52(5):344-348
- CountryRepublic of Korea
- Language:English
- Abstract: Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Pelvic computed tomography showed a large multilocular cystic mass, suspected to be of ovarian origin. We performed a total abdominal hysterectomy (total abdominal hysterectomy was performed) with bilateral salpingo-oophorectomy. A 13-cm multilocular cystic mass with serous fluid was observed in her right ovary. Upon microscopic examination, the solid component of the mass showed both Sertoli-Leydig cell and juvenile granulosa cell differentiation, which we diagnosed as gynandroblastoma. Gynandroblastoma with a juvenile granulosa cell tumor component is extremely rare and, until now, only six cases have been reported in the English literature. We report the first gynandroblastoma with a juvenile granulosa cell tumor component diagnosed in an elderly patient, along with a literature review.
