Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma: Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation
- Author:
Taebum LEE
1
;
Sangjoon CHOI
;
Joungho HAN
;
Yoon La CHOI
;
Kyungjong LEE
Author Information
- Publication Type:Case Report
- Keywords: BRD4-NUT fusion oncogene protein; NUT midline carcinoma; Lung; Cytology
- MeSH: Biopsy; Chromatin; Cytoplasm; Diagnosis; Early Diagnosis; Immunohistochemistry; Lung; Necrosis; Neutrophils; Nuclear Proteins; Nuts; Prevalence; Prognosis; Testis
- From:Journal of Pathology and Translational Medicine 2018;52(5):349-353
- CountryRepublic of Korea
- Language:English
- Abstract: Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and here we report two rare cases of thoracic NMC with cytohistologic correlation. In aspiration cytology, the tumor presented with mixed cohesive clusters and dispersed single cells, diffuse background necrosis and many neutrophils. Most of the tumor cells had scanty cytoplasm and medium-sized irregular nuclei, which had fine to granular nuclear chromatin. Interestingly, a few dyskeratotic cells or squamoid cell clusters were present in each case. Biopsy specimen histology revealed more frequent squamous differentiation, and additional immunohistochemistry tests showed nuclear expression of NUT. Because this tumor has a notorious progression and has been previously underestimated in terms of its prevalence, awareness of characteristic findings and proper ancillary tests should be considered in all suspicious cases.
