Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia
- Author:
Hyo Jeong KANG
1
;
Hui Jeong JEONG
;
So Woon KIM
;
Eunsil YU
;
Young Joo LEE
;
So Yeon KIM
;
Jihun KIM
Author Information
- Publication Type:Case Report
- Keywords: Carcinoma, hepatocellular; Adenoma, liver cell; Bone marrow metaplasia; β-catenin
- MeSH: Adenoma, Liver Cell; Bone Marrow; Carcinoma, Hepatocellular; Female; Humans; Liver; Metaplasia; Ultrasonography; Young Adult
- From:Journal of Pathology and Translational Medicine 2018;52(4):226-231
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.
