Hepatic Arterial Infusion Chemotherapy Using the Port System in Advanced Gallbladder Cancer
- Author:
Jong Ryeol EUN
1
;
Jae Woon KIM
;
Joon Hyuk CHOI
Author Information
- Publication Type:Case Report
- Keywords: Gallbladder cancer; Chemotherapy; Hepatic artery
- MeSH: Cisplatin; Drug Therapy; Fluorouracil; Gallbladder Neoplasms; Gallbladder; Hepatic Artery; Humans; Prognosis
- From:Korean Journal of Medicine 2018;93(1):50-54
- CountryRepublic of Korea
- Language:English
- Abstract: Gallbladder (GB) cancer is relatively rare and has a poor prognosis, with a median survival time of less than 3 months. It is resistant to chemotherapy. Therefore, the role of systemic chemotherapy is limited. However, administering the anticancer agent directly into the hepatic artery can result in a higher drug concentration in the cancer tissue. In this paper, we report a case of advanced GB cancer treated with hepatic arterial infusion chemotherapy (HAIC) using the port system. The patient received six cycles of HAIC with 5-fluorouracil (750 mg/m²) and cisplatin (25 mg/m²); each cycle lasted for 4 days every month. The tumor showed objective response during HAIC, and the patient survived for 15 months from the first therapy. HAIC using the port system might be a promising therapeutic modality for treating locally advanced GB cancer.
