A Case of Lactic Acidosis Caused by Linezolid Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia
- Author:
Yu Seok KIM
1
;
Ji Beom KIM
;
Yumi LEE
;
Sung Han KIM
;
Sang Ho CHOI
;
Jun Hee WOO
;
Yang Soo KIM
Author Information
1. Department of Internal Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. yskim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Lactic acidosis;
Linezolid;
Methicillin-resistant Staphylococcus aureus
- MeSH:
Acetamides;
Acidosis, Lactic;
Bacteremia;
Bacteria;
Bacterial Proteins;
Bone Marrow;
Humans;
Methicillin Resistance;
Methicillin-Resistant Staphylococcus aureus;
Optic Nerve Diseases;
Oxazolidinones;
Sclerotherapy;
Sepsis;
Varicose Veins;
Linezolid
- From:Korean Journal of Medicine
2012;82(4):512-515
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Linezolid is an antibiotic in the oxazolidinone family that works as a bacterial protein synthesis inhibitor. It is used for the treatment of Gram-positive, multidrug-resistant bacteria. Adverse effects of linezolid include bone marrow suppression, peripheral or optic neuropathy, and, less commonly, lactic acidosis. Lactic acidosis usually occurs as a result of cardiopulmonary failure or sepsis, but it is sometimes caused by drugs, such as linezolid, and treatment of such lactic acidosis involves cessation of the drug. We report a case of lactic acidosis caused by the use of linezolid for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia, which occurred after endoscopic sclerotherapy of gastic varices.
