Fatal Hypersensitivity Reactions Induced by Re-Administration of Rifampin in an Immunocompetent Patient with Tuberculous Lymphadenopathy
- Author:
Yeji KIM
1
;
Sun Young YIM
;
Song I BAE
;
Jae Hee AHN
;
Won Gin CHANG
;
Jang Wook SOHN
;
Min Ja KIM
Author Information
1. Division of Infections Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. yeji1224@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Rhabdomyolysis;
Rifampin
- MeSH:
Acute Kidney Injury;
Adult;
Anaphylaxis;
Exanthema;
Humans;
Hypersensitivity;
Critical Care;
Lymphatic Diseases;
Porphyrins;
Rhabdomyolysis;
Rifampin
- From:Korean Journal of Medicine
2012;82(1):115-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 44-year-old patient who had been diagnosed with tuberculous lymphadenopathy came to our hospital with a rash. He began to take antituberculous medications, but the next day, a rash appeared and persisted for one week. When he came to the hospital, he had already stopped the medication by his own decision. We stopped all drugs and reintroduced one drug at a time. After re-administration of rifampin, anaphylactic shock and subsequent acute renal failure and rhabdomyolysis occurred. Intensive care was performed, but the patient died 60 h after the first hypersensitive reaction that occurred due to rifampin. Anaphylaxis and subsequent rhabdomyolysis induced by rifampin is an extremely rare event. It is necessary to initially prescribe low dose rifampin in cases of re-administration.
