Effect of Sulgidduk containing pine needle juice on lipid metabolism in high fat-cholesterol diet induced dyslipidemic rats
- Author:
Yunjung LEE
1
;
Jae Hee PARK
;
Eunju PARK
Author Information
- Publication Type:Original Article
- Keywords: pine needle juice; sulgidduk; dyslipidemia; SREBP2; hepatic lipid profile
- MeSH: Animals; Cardiovascular Diseases; Cholesterol; Diet; Dyslipidemias; Eating; Erythrocytes; Feces; Gene Expression; Humans; Lipid Metabolism; Liver; Male; Medicine, Traditional; Models, Animal; Needles; Plasma; Rats; Rats, Sprague-Dawley; Risk Factors; Snacks; Thiobarbituric Acid Reactive Substances; Triglycerides; Weight Gain
- From:Journal of Nutrition and Health 2019;52(1):6-16
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Dyslipidemia is a major risk factor for cardiovascular disease. Pine needles (Pinus densiflora seib et Zucc) are a traditional medicine used to treat dyslipidemia in clinical settings. This study examined the potential effects of sulgidduk, a Korean traditional rice cake containing pine needle juice to protect against dyslipidemia induced by a high-fat/sugidduk diet in a rat model. METHODS: Twenty one male Sprague-Dawley rats were divided randomly into three groups: normal control (NC), Sulgidduk diet (SD), Sulgidduk diet containing pine needle juice (PSD). The blood lipid levels, production of lipid peroxide in the plasma and liver, total cholesterol and triglyceride in the liver and feces, antioxidant enzyme activities in plasma and erythrocytes were measured to assess the effects of PSD on dyslipidemia. RESULTS: A high-fat/Sulgidduk diet induced dyslipidemia, which was characterized by significantly altered lipid profiles in the plasma and liver. The food intake was similar in the three groups, but weight gain and food efficiency ratio (FER) were reduced significantly in the PSD group compared to those in the SD group. The level of total cholesterol, LDL-cholesterol and TBARS in the plasma showed tendencies to decrease in the PSD group compared to those in the SD group. The levels of high-fat/Sulgidduk diet-induced sterol regulatory element-binding protein 2 (SREBP2) gene expression were reduced significantly in the PSD group. The supplementation of PSD reduced the hepatic triglyceride and total cholesterol levels significantly, and enhanced the fecal excretion of triglyceride and hepatic antioxidant enzyme activities compared to the SD group. CONCLUSION: These results suggest that the addition of 0.4% pine needle juice to Sulgidduk may be an alternative snack to control dyslipidemia.
