Is There a Role of Pharmacological Treatments in the Prevention or Treatment of Osteonecrosis of the Femoral Head?: A Systematic Review
10.11005/jbm.2019.26.1.13
- Author:
Yun Jong LEE
1
;
Quanjun CUI
;
Kyung Hoi KOO
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
- Publication Type:Review
- Keywords:
Bone remodeling;
Diphosphonates;
Drug therapy;
Osteonecrosis
- MeSH:
Aspirin;
Bone Remodeling;
Diphosphonates;
Drug Therapy;
Enoxaparin;
Head;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Iloprost;
Osteonecrosis
- From:Journal of Bone Metabolism
2019;26(1):13-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Various pharmacological treatments have been suggested to treat osteonecrosis of the femoral head. However, their practicability remains a controversial issue. METHODS: We systemically reviewed articles published during last 20 years to assess the efficacy and safety of the pharmacological treatments. RESULTS: To date, enoxaparin, statins, bisphosphonates, iloprost and acetylsalicylic acid have been practiced for the treatment of osteonecrosis. However, none of them were proven to be effective by high level studies, and most of them have adverse reactions. CONCLUSIONS: No pharmacological prevention or treatment of osteonecrosis is recommendable at this moment.
