Effects of Thyrotropin Suppression on Bone Health in Menopausal Women with Total Thyroidectomy
10.11005/jbm.2019.26.1.31
- Author:
Eun Heui KIM
1
;
Yun Kyung JEON
;
Kyoungjune PAK
;
In Joo KIM
;
Seong Jang KIM
;
Seunghyeon SHIN
;
Bo Hyun KIM
;
Sang Soo KIM
;
Byung Joo LEE
;
Jeong Gyu LEE
;
Tae Sik GOH
;
Keunyoung KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Absorptiometry, photon;
Bone density;
Postmenopause;
Thyroid neoplasms
- MeSH:
Absorptiometry, Photon;
Body Mass Index;
Bone Density;
Bone Diseases, Metabolic;
Diagnosis;
Female;
Follow-Up Studies;
Humans;
Osteoporosis;
Postmenopause;
Spine;
Thyroid Neoplasms;
Thyroidectomy;
Thyrotropin;
Thyroxine
- From:Journal of Bone Metabolism
2019;26(1):31-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study examined the change in the trabecular bone score (TBS), areal bone mineral density (aBMD), and osteoporosis in postmenopausal women who underwent thyrotropin (TSH)-suppressive therapy for treating papillary thyroid cancer after a total thyroidectomy procedure. METHODS: We evaluated 36 postmenopausal women who received a total thyroidectomy for papillary thyroid cancer and were undergoing TSH suppressive therapy with levothyroxine. Postmenopausal women (n=94) matched for age and body mass index were recruited as healthy controls. The aBMD and TBS of the lumbar spine were compared between dual energy X-ray absorptiometry (DXA) at baseline and at follow-up after an average of 4.92 years. RESULTS: There was no significant difference in the rate of diagnoses of osteoporosis, osteopenia, or normal bone status between the 2 groups during the baseline DXA evaluation. However, the TBS was significantly lower whereas aBMD did not show significant difference at the time of baseline DXA measurement (1st DXA, 1.343±0.098 vs. 1.372±0.06317, P < 0.001; 2nd DXA, 1.342±0.095 vs. 1.370±0.062, P < 0.001). The TBS and aBMD did not differ significantly between the initial and follow-up DXA images in both groups of TSH suppressive patients and controls. CONCLUSIONS: The average value of TBS and aBMD did not significantly change during the follow-up period. The TSH suppressive therapy was revealed as not a significant factor for the progressive deterioration of bone status during long term follow-up.
