Impact on Bisphosphonate Persistence and Compliance: Daily Postprandial Administration
10.11005/jbm.2019.26.1.39
- Author:
Chan Ho PARK
1
;
Ki Jin JUNG
;
Jae Hwi NHO
;
Ja Hyung KIM
;
Sung Hun WON
;
Dong Il CHUN
;
Dong Won BYUN
Author Information
1. Department of Orthopaedic Surgery, Yeungnam University Medical Center, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Aperitif;
Bisphosphonate;
Compliance;
Daily;
Persistence;
Postprandial
- MeSH:
Alendronate;
Bone Density;
Breakfast;
Calcitriol;
Compliance;
Hip;
Humans;
Osteoporosis;
Radius Fractures;
Spine
- From:Journal of Bone Metabolism
2019;26(1):39-44
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Bisphosphonate (BP) is an effective drug for the prevention and treatment of osteoporosis. However, gastrointestinal distress caused by BP is a well-known side effect for low compliance. The aim of our study was to compare the 1-year persistence, compliance and T-scores between the aperitif medication group and the postprandial medication group. METHODS: Three hundred patients were included in this study to determine their persistence and compliance with the prescribed daily BP (Maxmarvil®, alendronate 5 mg and calcitriol 0.5 µg; YuYu Pharm) following distal radius fractures. Patients in Group 1 (aperitif medication) were asked to adhere to the general guidelines for BPs before breakfast. Patients in Group 2 (postprandial medication) were recommended medication after breakfast. We compared the persistence and compliance of this daily BP therapy using the medication possession ratio (MPR) and T-scores between the 2 groups after 1 year. RESULTS: Bone mineral density in hip and lumbar spine was improved significantly in 2 groups (P < 0.001). Significant differences existed between 2 groups, including 73 of 150 patients (48.7%) in Group 1, and 111 of 150 patients (73.3%) in Group 2 for 1-year persistence (P=0.001). The mean MPR is 0.66 in Group 1 (range, 0.50–0.86) and 0.71 in Group 2 (range, 0.54–0.87). A significant difference was detected between the 2 groups (P=0.002). CONCLUSIONS: Postprandial administration improved persistence and compliance with daily BP therapy, resulting in better clinical outcomes.
