Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report.
- Author:
Zhi Yu ZHU
1
;
Zhi Gang CHU
;
Yu CHEN
;
Wei Ping ZHANG
;
Di LV
;
Ning GENG
;
Ming Zhong YANG
Author Information
1. Department of Pathology, West China Hospital of Stomatology, Sichuan University, Sichuan, China. chen_yuhx@163.com
- Publication Type:Case Report
- Keywords:
Ghost cell odontogenic carcinoma;
Calcifying cystic odontogenic tumor
- MeSH:
Odontogenic Tumors
- From:Korean Journal of Pathology
2012;46(5):478-482
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.
