Rosai-Dorfman Disease in the Breast with Increased IgG4 Expressing Plasma Cells: A Case Report.
- Author:
Yoon Jin CHA
1
;
Woo Ick YANG
;
Se Ho PARK
;
Ja Seung KOO
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. KJS1976@yuhs.ac
- Publication Type:Case Report
- Keywords:
Breast;
Histiocytosis;
Immunoglobulin G;
Histiocytosis, sinus
- MeSH:
Breast;
Cytoplasm;
Emperipolesis;
Female;
Fibrosis;
Fluconazole;
Histiocytes;
Histiocytosis;
Histiocytosis, Sinus;
Humans;
Immunoglobulin G;
Middle Aged;
Plasma;
Plasma Cells;
S100 Proteins
- From:Korean Journal of Pathology
2012;46(5):489-493
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rosai-Dorfman disease (RDD) can present in any anatomic site, but breast involvement is rarely reported. Recently, a relationship between RDD and IgG4-related sclerosing disease has been suggested. Here we report another case of RDD with overlapping features of IgG4-related sclerosing disease occurring in a right breast of a 62-year-old female. On microscopic examination, the mass demonstrated a characteristic zonal pattern of proliferation of large polygonal histiocytes and lymphoplasma cells with stromal fibrosis. Emperipolesis was observed in histiocytes with abundant cytoplasm, which showed immunoreactivity for S-100 protein and CD68; the diagnosis of RDD was made. Sheets of plasma cells in the fibrotic stroma demonstrated positive reactions for IgG and IgG4. The mean count of IgG4-positive plasma cells was 100.2/high power field, and the ratio of IgG4/IgG was 56.7%. Additional findings of stromal fibrosis and obliteration of preexisting breast lobules suggested overlapping features with IgG4-related sclerosing disease.
